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Plague can presents in bubonic, septicemic and pneumonic forms. Bubonic plague presents with fever and painful swollen regional lymphnodes (bubo).

Plague carried by rodents and bubonic plague is transmitted through flea bites. In the United States plague is found in Western states. Untreated the mortality rate is very high.

Treatment is with IV or IM gentamicin or streptomycin. There are many other options for treatment including fluroquinolones, tetracyclines, and chloramphenicol.


American Academy of Pediatrics. Plague. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Red Book: 2018 Report of the Committee on Infectious Diseases. American Academy of Pediatrics; 2018;

Kwit N, Nelson C, Kugeler K, Petersen J, Plante L, Yaglom H, Kramer V, Schwartz B, House J, Colton L, Feldpausch A, Drenzek C, Baumbach J, DiMenna M, Fisher E, Debess E, Buttke D, Weinburke M, Percy C, Schriefer M, Gage K, Mead P. Human Plague - United States, 2015. MMWR Morb Mortal Wkly Rep. 2015 Aug 28;64(33):918-9. PubMed PMID: 26313475

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