Parentral penicillin G is the preferred therapy for all phases of syphilis.
Syphilis is described in four stages
- Primary with a localized ulcer at site of inoculation (chancer)
- Secondary which can occur one or two months later with fever, malaise, lymphadenopathy and mucocutaneous changes including palm involvement and resolves without treatment. This phase can mimic many other conditions.
- Latent phase which can last years to decades
- Tertiary syphilis including gumma, cardiac involvement and neurosyphilis
Treatment is with parentral penicillin G.
Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137.PMID: 26042815
American Academy of Pediatrics. Syphilis. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, eds. Red Book: 2018 Report of the Committee on Infectious Diseases. American Academy of Pediatrics; 2018;