Purulent skin infections are often caused by Staphylococcus aureus including MRSA.
Purulent skin infections are commonly caused by Staphylococcus aureus in contrast to non-purulent infections that may be more likely to be caused by Group A Streptococcus. Coverage should include community acquired MRSA. Prefered parenteral options in younger children include Vancomycin and Clindamycin (depending on local susceptibility patterns). Linezolid and TMP/SMX are alternatives with less clinical data to support their use.
Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC; Infectious Diseases Society of America. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clin Infect Dis. 2014 Jul 15;59(2):e10-52. PMID: 24973422